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This single nightly dose is often sufficient to provide robust and reliable suppression of violent dream-enactment behaviors throughout the entire sleep period. The patient in the United Kingdom or Australia who has been on a stable, long-term, moderate-to-high dose of Klonopin may report a gradual and insidious onset of symptoms that are indistinguishable from a major depressive episode: a profound and persistent lack of energy and motivation, a loss of interest in previously enjoyed activities, a sense of emotional blunting or detachment, and a general cognitive slowing or "brain fog." This is not because the Klonopin has lowered their serotonin levels, but because the overwhelming GABAergic inhibition has functionally muted the activity and responsiveness of the serotonergic and other excitatory pathways. Pills Keep You Awake. However, this pharmacologically induced state of unconsciousness is not equivalent to natural, restorative sleep, and the use of clonazepam for this purpose alone is fraught with significant long-term risks and is generally reserved for a very specific and narrow set of clinical circumstances where a primary, clonazepam-responsive sleep disorder has been definitively diagnosed. The benzodiazepine enhances the inhibitory power of GABA, which is widely distributed throughout the cortex, limbic system, and basal ganglia, effectively turning down the volume on the internal alarm that screams "Move or you will die!" For the patient in Vancouver or Manchester, this means that while the low-level, aberrant motor drive may still exist at the level of the basal ganglia, its translation into the conscious, terrifying, and all-consuming urge to pace is significantly blunted.

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